Patient care is being compromised by increasing rates of burnout among America’s clinicians, involving not only physicians, but also nurses, advanced practice providers, and other healthcare workers. Burnout can lead, in some cases, to tragic and even fatal consequences for both clinicians and patients. Because burnout affects the majority of clinicians and suicidal ideation is more common in health professional trainees and practicing physicians than the general public, there is an urgent need for structured and systematic improvements to improve the work life and well-being of our nation’s clinicians.